This Usher-syndrome patient from Japan gave us feedback after taking StemActiv for one week, two months, three months and six months. We pick up this patient’s follow-up, because he himself is also a medical staff, he has recorded his experience in detail. 1, After taking StemActiv for one week, he didn’t feel anything negative, night vision has got a little bit brighter. 2, After two months,his central vision blurriness was reduced, his visual field opened up, night vision improved. 3, Three months after taking ... Read more
It is widely held that following a healthy diet, exercising and reducing stress is beneficial to our health in general and also benefits our eyes, as regular and moderate physical exercise, activates micro-circulation and blood circulation, which brings more nutrients and oxygen to the optic cells. Aerobic and anaerobic exercise, which will benefit RP patients? Aerobic exercise has been found to be neuroprotective in animal models of retinal degeneration. It will lower intraocular pressure, which is pressure in your eyes, and that helps ... Read more
There are a few things that the eyes need to function properly: Oxygen, Nutrients, Glucose and constant neurological stimulation through specific ocular neurotransmitters. Reduced blood flow to the retina will cause accumulation of toxic and waste products in the eye tissue, it can also cause insufficient blood and oxygen supply to the optic cells. Toxins can cause obstruction, contamination, inflammation, degeneration and ultimately result in vision loss. Dormant optic cells may be inactive, but are not dead or totally dysfunctional. Many neuro ... Read more
Dietary supplementation with vitamin A is occasionally prescribed as a treatment for RP. However, there is one specific gene for which vitamin A is not recommended: ABCA4. This is because vitamin A accumulates toxic pigments in the retina and accelerates the progression of RP. It is not recommended that RP patients with the gene mutation ABCA4 take vitamin A. It is also recommended that people who take vitamin A supplements monitor liver function annually. Vitamin A is generally not recommended for ... Read more
The retina is considered a window to the brain, and retinal degeneration is a complex process involving environmental stress, which can affect vulnerable neurons. High-fat diet induced metabolic alterations may influence retinal homeostasis and accelerate RP deterioration. The scientific study provides evidence that short-term high-fat feeding promotes glucose intolerance. It also triggers the expression of inflammatory and oxidative markers in the retina, because the high-fat diet increases the abundance of potentially pro-inflammatory bacteria. Thus, it speeds up photoreceptor degeneration by promoting oxidative stress ... Read more
Recently we have received some patients’ inquiries, they are concerned they have been misdiagnosed and that unlike in the case of inherited sight loss, they want to know more about autoimmune retinopathy, AIR for short. What is AIR? Autoimmune retinopathy (AIR) is a term given for patients who have a rare autoimmune condition that results in loss of photoreceptor (rods and cones) function. The immune system protects us against infection, cancer and damaged cells. The orchestrators of the immune system are our white ... Read more
Feedback after taking herbal medicine for ten days: This RP patient from the UK gives us feedback after taking our herbal medicine. This voice message is after taking the herbal medicine for ten days. He felt a little bit clearer and the glare has reduced when going outside. Feedback after taking herbal medicine for two weeks: This feedback is after two weeks of using our medicine. His blurriness was reduced by 50%. His visual field opened up. Night vision improved. Feedback after taking herbal medicine ... Read more
Most RP mutations arise in rod photoreceptor genes, leading to diminished peripheral and night vision. To understand why cones die in RP and to be able to stop dying and revitalize dormant cones would be an enormous step forward. https://youtu.be/9xYkVagqSyY A group of researchers from the University of Louisville has made a step forward into reactivating dormant cones in the animal model of RP. First of all: why cones die in RP? Because rods allow the release of glucose from the Retinal Pigmented ... Read more
We noticed a comment on our Youtube channel (Restorerpvision) from a RP patient, who has just started taking StemActiv around two weeks. Here is his comment: I AM RP PATIENT.I JUST BOUGHT 6 MONTHS TREATMENT OF STEMACTIV PACKAGE I AM 41 YEAR OLD AND I HAVE CENTRAL VISION ONLY I STARTED TO SEE THE CHANGE IN THE CORNERS OF BOTH EYES OPENING LIGHTS ITS WORTH THE VALUE COMPARED THE BENEFIT. I AM TELLING FROM MY OWN EXPERIENCE I NOTICED THE CHANGE RIGHT ... Read more
This 19-year-old male patient suffers from Stargardt disease since childhood. His right eye vision declined dramatically in February 2021, due to fundus hemorrhage. Following are his OCT, FFA and ICGA images. Before StemActiv treatment, he could only see hand movement from the right eye. After the first VEGF treatment, his vision didn’t get change. His local doctor prescribed 6-months StemActiv and 3 times VEGF injections. In September 2021, his right eye vision improved from hand movement to 0.3, he can manage his ... Read more
The reduced vision in RP can be progressive photoreceptor cell death and treatable complications of RP, including cataractand macular edema. The major symptom of cataract is glare, especially in bright light. The cataract surgery time in RP is earlier than age-related cataract, with an average at 30 to 59 years old. The potential risks of cataract surgery, for example, ocular inflammation and increased eye pressure play a role in RP progression. During photoreceptor cell death, inflammatory cells are activated by releasing ... Read more
This 36-year-old female patient got diagnose with RP 7 years ago. She has lost about 80% central vision and 85% peripheral vision, she is using a walking stick and has registered legally blind. We have just received her brother’s message about the patient’s improvements in her vision since taking StemActiv. Less tiredness in the eyes.She used to see yellow squiggly lines in her vision between 8-10 times daily. Now she is reporting that she sees it around 1-2 times daily.Peripheral vision has ... Read more
This 65-year-old male patient has late-stage RP, his vision acuity was quite poor, he couldn’t go outside without somebody else help. After one year of continuous StemActiv treatment, his vision got tremendous improvement, fundus check shows the dark spots on his retina have reduced, OCT shows his retina thickness and optic nerve function gets normal. OCT after treatment: If you want to slow down your vision loss process, restore and even improve your vision function, please order the StemActiv treatment package on: https://www.restorevisionherbs.com/shop_stemactiv_product/ Read more
Inflammation, oxidative stress and poor ocular circulation are the top three factors that accelerate progressive vision loss in RP. Inflammation and optic cells death are tightly interconnected. Studies propose that inflammation is a consequence of the photoreceptor degeneration triggered by genetic defects. During photoreceptor cell death, inflammatory cells are activated by releasing inflammatory substances that contribute to rod and cone cell death. This eventually accelerates vision loss. While there are still no effective treatments for most degenerative retinal disorders, except for RPE65 ... Read more
Retinitis Pigmentosa (RP) is a devastating eye disease and at present, there are no known treatment options that can alter the rate of vision loss and eventual blindness. In a series of studies in animal models, the effects of exposing cones in the periphery of the retina to a large excess of oxygen results in progressive oxidative damage to cone photoreceptors and cone cell death. Cone cell death gradually spreads from the periphery of the retina toward its center, narrowing the visual ... Read more
On August 9th, 2021, recombinant adeno-associated virus vector carrying human CYP4V2 gene has obtained Orphan Drug Designations and Approvals by the US FDA. This gene therapy is offered by China Gene technology. It brings hope for RP patients with the gene mutation of CYP4V2, which is also called Bietti crystalline dystrophy. Retinitis pigmentosa, congenital macular dystrophy, optic nerve atrophy and other congenital hereditary eye disorders are like a train rushing to the darkness. If not treated, they will eventually lead to blindness. Gene ... Read more
Comparison of the Latest Stem Cell Therapies for RP Stem cell represents the most promising strategy for RP and other retinal diseases in the near future, and therapeutics assisted by gene techniques, neuroprotective compounds and artificial devices can be applied to fulfil the clinical needs for different kinds of retinal diseases patients. Till now, retinal progenitor cells (RPCs), induced pluripotent stem cells (iPS) and mesenchymal stem cells (MSCs) have finished early-stage clinical trials since they can all differentiate into RPE, photoreceptors or ... Read more
Gene therapy, in which we have very high expectations to cure genetic disorders, is currently being translated from preclinical assays to the clinical practice for retinal degeneration diseases, with successful achievement up till now for the LCA, due to mutations in the RPE65 gene. This gave hope to cure RP of different genetic origins.
Currently, our gene therapy research team is focusing on gene replacement therapy, gene editing therapy and optogenetic gene therapy. With these promising therapies, though, comes relevant challenges.
Over 300 ... Read more
Compared with gene therapy, stem cell treatment is more widely used for all kinds of gene mutation types of RP. Therefore, the research and development costs are more affordable in China. Stem cell treatment is just like we cannot cure hypertension, but we can manage the blood pressure and prevent stroke and other cardiovascular accidents via effective medication.
Eyes are immune privilege organ, stem cells will not be rejected when it’s inside the eyes. We can track where the stem cell goes ... Read more
Eleven advanced RP patients, with no light perception, or just perception of light in the study eye, and no better than counting fingers in the fellow eye, received intravitreal optogenetics gene therapy. They improved visual acuity from baseline at 16 weeks.
The single intravitreal injection targets bipolar cells instead of retinal ganglion cells. Optogenetics gene therapy turns bipolar cells into light-sensing activated neurons in response to light, making them the new photoreceptors of the retina.
Methods: Totally eleven patients were enrolled in the ... Read more
We found that a majority of our RP patients complained of light sensitivity or photophobia even in the absence of significant cataract. They most often complained of glare as irritation, pain, blurred vision, or a cause of tearing. The sun’s warm rays cause anguish, fluorescent lights at work make it hard to focus, the glare from the computer screen is more than just annoying. It’s probably the consequence of photoreceptor saturation or photochemical responsiveness, which is caused by the damage of the ... Read more
How COVID-19 and The Vaccines Impact RP Patients’ Vision
1, COVID-19 damages the vision and causes irreversible damage to the optic nerves
If a patient were in respiratory distress long enough, theoretically poor perfusion and oxygen deprivation could lead to possible damage to metabolically active tissues, such as the optic nerve or retina, but this has yet to be reported in COVID-19 related cases.
In this instance, eye damage would be caused by decreased oxygen, rather than the virus itself. Additionally, it has been ... Read more
Clinical observation on StemActiv in treatment of RP
(This scientific paper summary is from the Chinese Journal of Traditional Chinese Ophthalmology published in 2001.)
In 1999, China RP Integrative Treatment Center did a clinical trial to observe the treatment results of StemActiv for 198 RP patients.
We randomly divided 198 RP patients (312 eyes) into two groups. 138 RP patients (216 eyes) were treated mainly with StemActiv in the observed group, and 60 RP patients (96 eyes) were treated with Vitamin A and Lutein ... Read more
https://youtu.be/m2lpzUY2L7Y 1. Erectile dysfunction drugs ViagraSildenafil, the active ingredient in Viagra, can cause temporary vision changes, including blurred vision, sensitivity to light, reduced eyesight and changes to color perception. These side effects disappeared within a few days, however, it’s not known how exactly will Viagra affect RP patients’ vision by long term use. It’s worth taking into consideration if RP patients use it for the long term.
2. AccutaneUsed to treat acne, it has been reported to worsen night vision, ERG response, dark ... Read more
RP is one of the most common forms of inherited retinal degeneration which causes visual deficiency leading to blindness. The current treatment options include stem cell therapy, gene therapy, serum and nerve growth factor injection, stem cell activation (StemActiv), visual prosthesis, etc. Stem Cell Therapy: Stem cell therapy can potentially replace degenerate photoreceptors and retinal cells. When placed in the appropriate tissue niche, these stem cells not only survive but differentiate into critical retinal cells and photoreceptors. Further studies are needed to optimize ... Read more
Study outlines use of intravitreal injection of allogeneic human retinal progenitor cells to treat RP A phase 2B study was conducted of the efficacy of the regenerative medicine advanced therapy (RMAT) -designated intravitreal injection of allogeneic human retinal progenitor cells (hRPCs) (jCell, jCyte Inc.) to treat retinitis pigmentosa (RP).
The study showed that in the high-dose patient group, there was a significant correlation between all visual function changes measured over the 12-month study and the optical coherence tomography (OCT) measurement of the central ... Read more
Natural Remedy to Restore RP Vision: Fiction or Fact?
RP patients’ vision loss comes on slowly and methodically, depending on their gene mutation type and the overall health condition of the person in distress. Gradual vision loss is even more frustrating for those who may not develop noticeable symptoms until the disease has become severe. While the best strategy for healthy eyes is early detection and prompt intervention. However, the question remains: Do natural remedies play a role in the prevention of ... Read more
Comparison Of The 5 Advanced Treatments For RP
The most advanced treatments for RP in 2020 are gene therapy, stem cell therapy, serum therapy, intelligent visual implant, herbal products. The different indications of these 5 treatments are:
1. Gene therapy: for a certain type of gene mutation, it’s especially for early-stage patients, who have relatively good original vision function. Gene therapy is to slow down the deterioration of the retina, but it cannot improve the vision acuity. Till now, the only gene therapy ... Read more
Top ６ Retinitis Pigmentosa Treatments in 2020 Can Retinitis Pigmentosa be cured? With all the research on retinitis pigmentosa and advances in RP treatments, it’s tempting to think someone has surely found an RP cure. Unfortunately, there is no way to be found to cure all types of RP by now. However, there are some treatments that can slow down retinal degeneration to preserve vision for a longer time.
Here are the top 6 Retinitis Pigmentosa treatments available in 2020.
1, Serum treatment: Retrobulbar ... Read more