Compared with gene therapy, stem cell treatment is more widely used for all kinds of gene mutation types of RP. Therefore, the research and development costs are more affordable in China. Stem cell treatment is just like we cannot cure hypertension, but we can manage the blood pressure and prevent stroke and other cardiovascular accidents via effective medication. Eyes are immune privilege organ, stem cells will not be rejected when it’s inside the eyes. We can track where the stem cell goes ...Read more
Eleven advanced RP patients, with no light perception, or just perception of light in the study eye, and no better than counting fingers in the fellow eye, received intravitreal optogenetics gene therapy. They improved visual acuity from baseline at 16 weeks.
The single intravitreal injection targets bipolar cells instead of retinal ganglion cells. Optogenetics gene therapy turns bipolar cells into light-sensing activated neurons in response to light, making them the new photoreceptors of the retina.
Methods: Totally eleven patients were enrolled in the ...Read more
We found that a majority of our RP patients complained of light sensitivity or photophobia even in the absence of significant cataract. They most often complained of glare as irritation, pain, blurred vision, or a cause of tearing. The sun’s warm rays cause anguish, fluorescent lights at work make it hard to focus, the glare from the computer screen is more than just annoying. It’s probably the consequence of photoreceptor saturation or photochemical responsiveness, which is caused by the damage of the ...Read more
How COVID-19 and The Vaccines Impact RP Patients’ Vision
1, COVID-19 damages the vision and causes irreversible damage to the optic nerves If a patient were in respiratory distress long enough, theoretically poor perfusion and oxygen deprivation could lead to possible damage to metabolically active tissues, such as the optic nerve or retina, but this has yet to be reported in COVID-19 related cases. In this instance, eye damage would be caused by decreased oxygen, rather than the virus itself. Additionally, it has been ...Read more
Clinical observation on StemActiv in treatment of RP
(This scientific paper summary is from the Chinese Journal of Traditional Chinese Ophthalmology published in 2001.)
In 1999, China RP Integrative Treatment Center did a clinical trial to observe the treatment results of StemActiv for 198 RP patients. We randomly divided 198 RP patients (312 eyes) into two groups. 138 RP patients (216 eyes) were treated mainly with StemActiv in the observed group, and 60 RP patients (96 eyes) were treated with Vitamin A and Lutein ...Read more
https://youtu.be/m2lpzUY2L7Y 1. Erectile dysfunction drugs ViagraSildenafil, the active ingredient in Viagra, can cause temporary vision changes, including blurred vision, sensitivity to light, reduced eyesight and changes to color perception. These side effects disappeared within a few days, however, it’s not known how exactly will Viagra affect RP patients’ vision by long term use. It’s worth taking into consideration if RP patients use it for the long term.
2. AccutaneUsed to treat acne, it has been reported to worsen night vision, ERG response, dark ...Read more
RP is one of the most common forms of inherited retinal degeneration which causes visual deficiency leading to blindness. The current treatment options include stem cell therapy, gene therapy, serum and nerve growth factor injection, stem cell activation (StemActiv), visual prosthesis, etc. Stem Cell Therapy: Stem cell therapy can potentially replace degenerate photoreceptors and retinal cells. When placed in the appropriate tissue niche, these stem cells not only survive but differentiate into critical retinal cells and photoreceptors. Further studies are needed to optimize ...Read more
Study outlines use of intravitreal injection of allogeneic human retinal progenitor cells to treat RP A phase 2B study was conducted of the efficacy of the regenerative medicine advanced therapy (RMAT) -designated intravitreal injection of allogeneic human retinal progenitor cells (hRPCs) (jCell, jCyte Inc.) to treat retinitis pigmentosa (RP).
The study showed that in the high-dose patient group, there was a significant correlation between all visual function changes measured over the 12-month study and the optical coherence tomography (OCT) measurement of the central ...Read more
Natural Remedy to Restore RP Vision: Fiction or Fact?
RP patients’ vision loss comes on slowly and methodically, depending on their gene mutation type and the overall health condition of the person in distress. Gradual vision loss is even more frustrating for those who may not develop noticeable symptoms until the disease has become severe. While the best strategy for healthy eyes is early detection and prompt intervention. However, the question remains: Do natural remedies play a role in the prevention of ...Read more
Comparison Of The 5 Advanced Treatments For RP
The most advanced treatments for RP in 2020 are gene therapy, stem cell therapy, serum therapy, intelligent visual implant, herbal products. The different indications of these 5 treatments are:
1. Gene therapy: for a certain type of gene mutation, it’s especially for early-stage patients, who have relatively good original vision function. Gene therapy is to slow down the deterioration of the retina, but it cannot improve the vision acuity. Till now, the only gene therapy ...Read more